Behavioral and pharmacological evaluation of central 5-HT functions in spontaneously hypertensive rat
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چکیده
منابع مشابه
Ketanserin-induced baroreflex enhancement in spontaneously hypertensive rats depends on central 5-HT(2A) receptors.
1. Ketanserin may influence baroreflex function by blocking 5-HT(2A) receptors and/or alpha(1)-adrenoceptors through central and/or peripheral mechanisms. 2. In the present study, we tested the hypothesis that the baroreflex sensitivity (BRS)-enhancing effects of ketanserin are mediated by central 5-HT(2A) receptors in spontaneously hypertensive rats (SHR). 3. Using a conjugate of a monoclonal ...
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The role of central nervous system in the resetting of baroreflex was investigated in 5-month-old spontaneously hypertensive rats (SHR) of Okamoto strain. Age-matched Wistar-Kyoto (WKY) rats were used as normotensive controls. The aortic nerves, which in the rat, contain few or no chemoreceptor fibers, were stimulated electrically using a wide range of stimulus frequencies. The depressor respon...
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NOSAKA, SCHOICHIRO, AND S. C. WANG. Carotid sinus baroceptor function in the spontaneously hypertensiae rat. Am. J. Physiol. 222(5): 1079-1034. 1972.--Carotid sinus baroceptor function in the spontaneously hypertensive rat (SHR) was studied by isolating and perfusing the sinuses at various perfusion pressures and recording the systemic arterial pressure responses. Under steadystate conditions f...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)49451-1